RESUMO
Eosinophilic cystitis (EC) is an uncommon inflammatory disorder of uncertain etiology that has been described in adult and pediatric populations. We describe 3 recent cases of EC that presented as a mass lesion in pediatric patients from the New England region of the United States. All patients were initially suspected to have a malignancy, and biopsy was performed, which ultimately led to the diagnosis of EC. We propose the use of eosinophil density of >25 eosinophils per high-power field and myocyte degeneration as supportive histopathologic features to make this diagnosis. It is of utmost importance to consider EC in the differential diagnosis when approaching a pediatric patient with a bladder mass.
Assuntos
Cistite/diagnóstico , Eosinofilia/diagnóstico , Eosinófilos/patologia , Bexiga Urinária/diagnóstico por imagem , Adolescente , Anti-Inflamatórios/administração & dosagem , Biópsia , Pré-Escolar , Cistite/terapia , Diagnóstico Diferencial , Eosinofilia/terapia , Humanos , Hidrocortisona/administração & dosagem , Contagem de Leucócitos , Imageamento por Ressonância Magnética , Masculino , Tomografia Computadorizada por Raios X , Ultrassonografia , Procedimentos Cirúrgicos Urológicos Masculinos/métodos , Urotélio/patologiaRESUMO
Since its discovery in the late 1990s as a signaling molecule in the Ras/Ral pathway, Reps2 has emerged as an important player in receptor-mediated endocytosis. Reps2 contains Eps15 homology (EH) domains, proline-rich regions, and a coiled-coil domain that engage in several protein-protein interactions to coordinate the internalization of various receptors with molecular signaling. Reps2 has clinical importance as it suppresses the ability of its binding partner RalBP1 to transport chemotherapeutic drugs, such as doxorubicin, out of a cell. Reps2 is also dysregulated during the progression of prostate cancer and is a potential biomarker for breast and prostate cancer.
